OncoBEAM™ for metastatic colorectal cancer (mCRC) delivers rapid results to drive treatment decisions with real-time information about clinically actionable mutations in genes such as RAS and BRAF. The National Comprehensive Cancer Network (NCCN), American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) guidelines1-3 all recommend RAS and BRAF mutation testing before prescribing anti-EGFR therapy.
Thanks to our highly-sensitive BEAMing technology, a liquid biopsy with OncoBEAM™ requires only a simple blood draw to provide a current view of a tumor’s mutation status in 5 to 7 days.
OncoBEAM™ assays for colorectal cancer provide results in just 5 to 7 days from our CLIA-certified laboratory, helping doctors to make faster treatment decisions for patients.
Emergence of resistance mutations is common in metastatic colorectal cancer (mCRC) patients treated with anti-EGFR therapy.4,5 The OncoBEAM™ test has been shown to reveal these resistance mutations sooner than imaging6,7 providing early insight to plan for next steps.
KRAS/NRAS: Codons 12, 13, 59, 61, 117, and 146
BRAF: V600E, V600K
HRAS: Codon 61
KRAS mutations in Codons 12 and 13 are no longer the sole mutations that guide therapy decisions. Patients with mCRC tumors exhibiting a new RAS mutation are unlikely to significantly benefit from anti-EGFR therapy.8
The extensive OncoBEAM™ RAS panel provides oncologists with an accurate assessment of RAS mutation status to assist in identifying appropriate therapy options for mCRC patients.
Additional RAS mutations in codons other than 12 and 13 in KRAS and also including NRAS were revealed in approximately 15% of patients originally classified as wild type through tissue testing8
BRAF mutations are associated with resistance to anti-EGFR therapy. Patients whose tumor harbors a BRAF mutation generally have poor outcomes and have not been shown to benefit from anti-EGFR therapy.9 However, new data from recent clinical trials combining BRAF inhibitors with anti-EGFR therapy show have shown promising results.6,7
The OncoBEAM™ CRC1 mutation test includes BRAF to provide a comprehensive analysis of clinically actionable mutations as recommended by clinical practice guidelines.3
A 65 year old man presents with metastatic colorectal cancer upon routine screening. Imaging reveals liver lesions that are unresectable due to size and insufficient future liver remnant. Systemic therapy is recommended to attempt conversion to resectable hepatic disease. In accordance with clinical practice guidelines, tumor RAS/BRAF status must first be evaluated.
OncoBEAM™ CRC1 testing is ordered to evaluate the mutational status of both primary and metastatic sites. Testing reveals a RAS mutant tumor, eliminating consideration of anti-EGFR therapy.
The OncoBEAM™ solution
OncoBEAM™ CRC1 test enabled a systemic mutation assessment of the patient’s tumor mutation status without the need for multiple invasive biopsies at each site.
BEAMing is a highly sensitive quantitative PCR technology that employs bead-based amplification in water-in-oil emulsions and allele-specific hybridization followed by flow cytometry for detecting small amounts of mutated DNA released by tumors into the blood circulation. Our BEAMing assays are designed to detect specific clinically relevant hotspot mutations and can be used to calculate the fraction of circulating DNA that contains a specific mutation at the time a sample is drawn.
The advantages of BEAMing technology include:
No, BEAMing today is used for mutation testing in advanced and metastatic cancer patients.
Sysmex Inostics accepts all insurance plans, but OncoBEAM™ tests are currently not in-network with most carriers. We are working to become in-network with payors. Sysmex Inostics directly bills insurance or Medicare and patients are not responsible for any balance that is not covered by insurance or Medicare. Deductibles may apply if applicable. Sysmex Inostics does not accept uninsured patients at this time.