While clinical practice guidelines already encourage molecular testing to advise metastatic melanoma treatment options, clinicians need a faster, clearer picture of disease progression.
Thanks to our highly-sensitive BEAMing technology, a liquid biopsy with OncoBEAM™ requires only a simple blood draw to access tumor DNA and provide a real-time view of a tumor’s mutation status in 5 to 7 days.
OncoBEAM™ assays for melanoma provide results in just 5 to 7 days from our CLIA-certified laboratory, helping doctors to make faster treatment decisions for patients.
OncoBEAM™ BRAF and NRAS assays detect ctDNA to deliver results a physician can use to monitor a patient’s cancer progression, and response to treatment.1 Combined with standard of care medical imaging, OncoBEAM™ test results can help streamline patient management by providing unique insight into tumor activity.
NRAS: Codon 61
BRAF: V600E, V600K
BRAF: V600E, V600K
Melanoma tumors with activating BRAF mutations are shown to respond to BRAF inhibitors, improving overall response rates and prolonging survival rates when compared to chemotherapy.2 The most common BRAF-activating mutations occur at residue V600.3
OncoBEAM™ BRAF can detect the V600E and V600K mutations, allowing physicians to make more rapid treatment decisions based on a systemic mutation assessment of a patient’s tumor.
Approximately 40 to 50% of melanoma tumors harbor BRAF mutations.3
Despite high initial response rates to BRAF-targeted monotherapy, about half of patients develop drug resistance in six months. NRAS mutations are associated with therapy resistance in up to 20% of patients receiving BRAF inhibitor therapy.5,6
OncoBEAM™ can detect detect the most frequently mutated NRAS mutations, helping to provide insight into potential therapy resistance.
About 15 to 20% of melanoma tumors harbor NRAS mutations.4
A 43-year-old patient arrived at a hospital with a large, unusual bleeding mass and a low hematocrit of 21%.
The OncoBEAM™ solution
The OncoBEAM™ biopsy revealed a BRAF V600E mutation in just three days (10 fewer than the tissue biopsy). The patient was immediately put on combination BRAF/MEK inhibitor therapy and experienced a rapid response.
Yes. Clinically actionable multigene detection panels are available to assess the mutational status of a tumor.
Yes. Plasma mutation status correlates well with response to therapy and there is a growing body of evidence showing that it can be used to predict disease progression.7,8
ctDNA refers to small fragments of DNA that are not associated with cells or cell fragments released from a tumor into the bloodstream. Circulating Tumor Cells (CTCs) are cells shed from primary and/or metastatic tumor deposits and circulate in the bloodstream. CTCs may constitute seeds for subsequent growth of additional tumors (metastases) in vital distant organs.
There are indications that ctDNA is often present without detectable CTCs. ctDNA levels may be higher than CTCs in certain tumor types. Some studies have also shown that ctDNA has greater sensitivity for mutation detection than CTCs.8
Sysmex Inostics accepts all insurance plans, but OncoBEAM™ tests are currently not in-network with most carriers. We are working to become in-network with payors. Sysmex Inostics directly bills insurance or Medicare and patients are not responsible for any balance that is not covered by insurance or Medicare. Deductibles may apply if applicable. Sysmex Inostics does not accept uninsured or Medicaid patients at this time.